Polygonum cuspidatum is native to eastern Asia and widely distributed in China. Polygonum cuspidatum have been used in traditional Japanese and Chinese medicine to treat a wide range of afflictions, including fungal diseases, various skin inflammations, cardiovascular diseases and liver diseases.

1. Antipyretic and Analgesic Activity
2. Anti-cancer and Anti-mutagen Activity
Resveratrol exhibits cancer chemo-preventive activity by acting as an antioxidant, an antimutagen, and an anti-inflammatory agent. It also induces human promyelocytic leukemia cell differentiation (anti-progression activity) and inhibits the development of preneoplastic lesions. Resveratrol can also inhibit protein-tyrosine kinase, which catalyzes the phosphorylation of tyrosine. This kinase is involved in signal transduction in the cytoplasm of a cell involved in the regulation of mitogenesis. The inhibition of protein-tyrosine kinase by resveratrol is possibly antimutagenic by detering the kinases function.
3. Prevention of Heart and Liver Damage Resveratrol inhibits the deposition of triglycerides and cholesterol in the liver of mice. It also reduces the elevation of aspartate transaminase and alanine transaminase. Analysis of these two enzymes in blood serum gives good diagnostic information for heart and liver damage.
4. Antithrombotic Activity Resveratrol inhibits lipoxygenase production, which are enzymes found in leukocytes, the heart, brain,lung, and spleen. Thus resveratrol prevents the formation of blood clots within blood vessels. It also inhibits platelet aggregation after treatment with clonidine, an antihypertensive drug.
5. Immune System Improvement in Wound Healing