The chemical name of Dienogest is 17¦Á-cyanomethyl -17¦Â-hydroxy-13¦Â-methyl sterane-4,9-diene-3-ketone which is new contraceptive medicine produced by German Schering. It has accurate effect and small side effect becoming first oral contraception. Dienogest is mixed progestogen with dual natures of 19- nor testosterone derivative and progesterone derivative of unique pharmacodynamics and medical kinematics. Dienogest has 17¦Á - cyanogen methyl group which is different from 19- nor testosterone derivative on.

ª¦Single-phase compound piece of Dienogest and ethinyloestradiol (DNG/EE)2mg/30pg went into the market by JnePaharmGmbH&Co.KG in Germany in 1995, the trade name is Valette as oral contraceptive which is high and reliable, low hemorrhage and best-selling in Germany. Compound piece of Dienogest 2mg and estradiol valerate 2mg (EZv/DNG) went to the market by ShcernigAG as commodity Climodine in 2002, which is first continual used in treating menopause and substituted (HRT). It went to Japan market in 2007, specification: 1mg, used in endometriosis. It belongs to chemicals 3 ¡¤ 1.

Structural formula:

Molecular formula: C₂0H₂₅NO₂ ¡¡¡¡Molecular weight: 311.42¡¡¡¡CAS:

Characters:

Dienogest yellow to white crystal powder, it dissolves in chloroform, methylene chloride, slight in acetone, methyl alcohol, ethyl alcohol, ethyl acetate, does not dissolve in the water.