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| (S)-10-Hydroxycamptothecin |
Basic info.
Alias:(4S)-4-Ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; 10-
Hydroxycamptothecin; 10-Hydroxycamptothecine; NSC 107124
Molecular structure:
Molecular formula:C20H16N2O5
Molecular weight:364.35
CAS RN:19685-09-7
Quality standard
| Quality standard:WS1-XG-014-2001 |
| Inspection standard |
Standard |
Result |
| Appearance |
yellow powder or crystalline powder |
light yellow needle-like crystalline powder |
| Identification |
(1)in accordance with ultraviolet absorption;
(2)in accordance with infrared absorption spectrum . |
qualified |
| Clarity and color of solution |
clear or not darker than 8# standard liquid |
qualified |
| Solubility |
slight soluble in methanol, absolute ethanol and diluted alkali, insoluble in water |
qualified |
| Melting point |
266-268℃ |
267 |
| Assay test |
LC(area normalization) |
| (S)-10-Hydroxycamptothecin |
≥98.0% |
≥99.0% |
| Camptothecin |
≤2.0 % |
≤1.0 % |
| Unknown impurity |
≤0.5% |
Na |
| Loss on dry |
≤5.0 % |
qualified |
| (Residue on ignition) |
≤ 1.0% |
qualified |
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