Microorganism catalysis by microbial catalytic method:
Microorganism fermentation produces nitrile hydratase , the nitrile hydratase can catalyse  3-Cyanopyridine  to give the Nicotinamide under the room temperature.
The process has proposed selectivity of substrate, high purity, temperate response and less pollution.

We adopt microorganism catalysis to produce Glycolic acid. Microorganism fermentation produces nitrilase which catalyse  glycolonitrile to produce Glycolic acid under the room temperature. The craft has proposed selectivity of substrate, high purity, temperate response, simple depuration, not high demand of equipment and environment.